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I've spent my fair share of time dealing with the Advanced TDMS API to achieve the same thing: decimating the data to plot them in a graph. My benchmarking showed that there is a sweet spot where performing one Read operation for each sample you want to keep (using the Offset hooovahh was talking about) starts being more efficient than performing a single Read operation returning a giant amount of data and then keeping only 1 every 100 samples for example. So I'd recommend looking into that if you go with a TDMS-based solution. And since we are dealing with files on disk: SSD drive!! Forget about HDD, way too slow, your users will have to wait several seconds each time they need to refresh the graphs. And yes, cut the file size by half by using SGL instead of DBL! This only poses an issue for the timestamp since LabVIEW uses DBL. I worked around this by using 3 SGL columns to represent the timestamp. You're on the right track!