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If I am reading the directions correctly, you can break this reading up into sections: (character 1) T1 Polarity = + (characters 2-7) T1 Value = 0x0056A4 = 22180 (character 8) Thermocouple Type = K (character 9) T2 Polarity = + (characters 10-15) T2 Value = 0x005640 = 22080 (character 16) Unknown = _ (character 17-22) Timer =000353 (character 23-30) Meter Status = ________ (character 31) = Carriage Return (part of a new line character) (character 32) = Line Feed (also part of a new line character) The calculation shown is to convert a hex value to a decimal value and scale it into an actual temperature (divide by 1000). Mentioning MSD and LSD is just so you can order the Hex value correctly when converting to decimal. 0x0056A4 = 0 * 16^5 + 0 * 16^4 + 5 * 16^3 + 6 * 16^2 + A * 16^1 + 4 * 16^0 = 0 * 1048576 + 0 * 65536 + 5 * 4096 + 6 * 256 + 10 * 16 + 4 * 1 = 0 + 0 + 20480 + 1536 + 160 + 4 = 22180 Your temperatures are 22.180 and 22.080 (not sure what unit; probably degrees Celsius). In LabVIEW, you can use code similar to the following to make the conversion: Conversion Example.vi