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Two suggestions: 1) Consider using JSON as your config-data format, rather than clusters. Using JSONtext to manipulate JSON will be faster than using OpenG tools to manipulate clusters. 2) Programmatically get an array of references to all your config-window controls and register a single Event case for Value Change of any one of them. Then use their (hidden) labels to encode what config item they set. For example, your control with the caption "Baud Rate" could have the hidden label "$.Serial Settings.Baud Rate" which is the JSONpath to set in your config JSON (or config clusters).

The SQLite API for LabVIEW had a feature for that. Very easy with a database. I suppose you could do something similar just by saving and loading a particularly named JSON file.