Lots of experience. For some reason I keep trying to use it, even tho it rarely does anything. As Ben says, the whole calling chain has to go away before it works.
You're using LV 2010, right? It should be already Large Address Aware, but if you're using 8.6 take a look here.
Yes, contiguous memory is the problem with large data sets, particularily when you're trying to plot them.
Before I pull in a large amount of data, I read the available system memory, divide it in half, and then decimate my data to fit in that space. Yes, it's a WAG that even that will be enough memory (not to mention really frustrating to have lots of memory out there and not be able to use it), but it's been working pretty well so far.