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Shameless plug: Proper Way to Communicate Over Serial

You can run multiple instances of the same LabVIEW version by adding the following key in your LabVIEW.ini file AllowMultipleInstances=True I have never tried to have more than one L Instance running the application builder at the same time... Now that I think of if it, I've never even tried to use an instance for coding while another instance is compiling. LabVIEW crashes so well without trying all that... I rarely run multiple instances at the same time anyway. The alternative I can suggest is to use a dedicated build machine (virtual or not depending on you IT infrastructure)

Check this out https://fabiensanglard.net/gebb/index.html I just wish I had time (and the brainpower!) to do a deep dive.